XBI · WMTMT

Dec 31Mar 3Apr 29Jun 29Aug 25

Breadth

108 / 147

stocks rose with the index

Concentration

18%

of the gain from MRNA, TWST, ERAS

Biggest driver

MRNA +4.21

MODERNA INC, +438.59%

Biggest drag

CAPR −1.09

CAPRICOR THERAPEUTICS INC, −71.28%

What drove it

147 members · drivers first · YTD · residual 539.6bp exceeds 60bp gate

The XBI rose 38.70% (+47.19 pts) so far this year in a broad advance: 108 of 147 stocks rose, with MRNA out front at +4.21 points.

Read the latest market-close note: Nvidia and Goldman Sachs Lead a Narrow Advance as Energy and Staples Slide

+56.8 pts from 114 gainers−9.7 pts from 33 losers

net +47.2 pts · gainers outweigh losers 5.9 to 1

Stock

Points

Return

XBIsum of all 147 stocks

+47.2

+38.70%

MRNAMODERNA INC

+4.2

+438.59%

TWSTTWIST BIOSCIENCE CORP

+2.6

+377.36%

ERASERASCA INC

+1.9

+377.42%

SYRESPYRE THERAPEUTICS INC

+1.5

+227.72%

ORKAORUKA THERAPEUTICS INC

+1.4

+235.93%

SLSSELLAS LIFE SCIENCES GROUP I

+1.4

+273.74%

DNTHDIANTHUS THERAPEUTICS INC

+1.4

+172.05%

CRSPCRISPR THERAPEUTICS AG

+1.3

+16.13%

IOVAIOVANCE BIOTHERAPEUTICS INC

+1.2

+209.16%

KYMRKYMERA THERAPEUTICS INC

+1.2

+62.76%

RLAYRELAY THERAPEUTICS INC

+1.2

+143.14%

IBRXIMMUNITYBIO INC

+1.2

+313.64%

PTGXPROTAGONIST THERAPEUTICS INC

+1.1

+72.42%

RVMDREVOLUTION MEDICINES INC

+1.1

+165.39%

APGEAPOGEE THERAPEUTICS INC

+1.1

+78.66%

117 othersclick to expand the full index

+31.1

IONSIONIS PHARMACEUTICALS INC

−0.3

−19.64%

SIONSIONNA THERAPEUTICS INC

−0.3

−84.81%

UTHRUNITED THERAPEUTICS CORP

−0.3

+6.42%

SMMTSUMMIT THERAPEUTICS INC

−0.3

−23.61%

QUREUNIQURE NV

−0.3

+113.33%

MPLTMAPLIGHT THERAPEUTICS INC

−0.3

−28.61%

MNKDMANNKIND CORP

−0.4

−26.63%

OLMAOLEMA PHARMACEUTICALS INC

−0.4

−56.36%

SRPTSAREPTA THERAPEUTICS INC

−0.5

−12.08%

VERAVERA THERAPEUTICS INC

−0.6

−30.33%

MIRMMIRUM PHARMACEUTICALS INC

−0.6

+24.17%

ADMAADMA BIOLOGICS INC

−0.7

−46.71%

ALNYALNYLAM PHARMACEUTICALS INC

−0.8

−39.63%

INSMINSMED INC

−1.0

−28.82%

CAPRCAPRICOR THERAPEUTICS INC

−1.1

−71.28%

Cap weighting, illustrated

ARROWHEAD PHARMACEUTICALS IN and DAMORA THERAPEUTICS INC moved almost identically (+33.88% vs +33.07%), yet ARWR moved the XBI 58.2× as much. In a cap-weighted index, the bigger company's weight turns the same percentage move into far more points.

Attribution map

slicing the +47.19 pt move · cell size = points contributed · color = direction, intensity = return

MRNA+4.2 pts(+438.6%)

TWST+2.6 pts

ERAS+1.9 pts

SYRE+1.5 pts

ORKA+1.4 pts

SLS+1.4 pts

DNTH+1.4 pts

CRSP+1.3 pts

IOVA+1.2 pts(+209.2%)

KYMR+1.2 pts(+62.8%)

RLAY+1.2 pts

IBRX+1.2 pts

PTGX

RVMD+1.1 pts

APGE+1.1 pts

CAPR−1.1 pts

TVTX+1.1 pts

TGTX

NVAX

NTRA+1.0 pts

INSM−1.0 pts

CGON

PURR+0.9 pts

HALO+0.9 pts

IMVT+0.8 pts

NTLA+0.8 pts

KRYS

ARWR

ROIV+0.8 pts

ALNY−0.8 pts

ADMA

GRAL

CDNA

MIRM−0.6 pts

XNCR+0.6 pts

DNLI

DYN

TNGX

TRAX

SRRK

SRPT

ABSI

BEAM

INCY

AMGN

IDYA

27 more

AVTX

MNKD

RCUS

NRIX

VRDN

QURE

SMMT

ANAB

INBX

CADL

VRTX

UTHR

CRVS

IRON

RARE

IONS

IRWD

IMMX

BBIO

MLYS

ACAD

ANNX

Concentration curve

cumulative share of the +47.19 pt move · sorted by contribution

When they drove it

cumulative points through the period

Breadth

member returns, this period

−100%0%+100%+200%+300%+400%

From −84.81% (SION) to +438.59% (MRNA). Equal-weight, the XBI would be +49.61% vs the actual +38.70%; the gap is what cap weighting did.

By sector

point contribution · sums to +47.19 pts

-147

+47.1

The year, session by session

every trading day of 2026 · hover for the move

JANFEBMARAPRMAYJUNJULAUG

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SPDR S&P Biotech ETF

What drove it

Attribution map

Concentration curve

When they drove it

Breadth

By sector

The year, session by session

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