XBI · WMTMT

Oct 4, 2024Apr 8, 2025Oct 9, 2025Apr 10, 2026Oct 9, 2026

Breadth

93 / 157

stocks rose with the index

Concentration

17%

of the gain from MRNA, TWST, GRAL

Biggest driver

MRNA +3.94

MODERNA INC, +273.75%

Biggest drag

SRPT −4.76

SAREPTA THERAPEUTICS INC, −85.17%

What drove it

157 members · drivers first · 2Y · residual 2232.3bp exceeds 60bp gate

The XBI rose 57.68% (+56.24 pts) over two years on a mixed tape; MRNA, TWST, GRAL did most of the lifting, with 17% of the gain between them.

Read the latest market-close note: Goldman and Microsoft Push the Dow to a Large Gain While Telecoms Sink Communication Services

+74.2 pts from 94 gainers−24.5 pts from 63 losers

net +56.2 pts · gainers outweigh losers 3.0 to 1

Stock

Points

Return

XBIsum of all 157 stocks

+56.2

+57.68%

MRNAMODERNA INC

+3.9

+273.75%

TWSTTWIST BIOSCIENCE CORP

+3.1

+268.67%

GRALGRAIL INC

+2.7

+978.89%

NTRANATERA INC

+2.3

+208.62%

ERASERASCA INC

+2.2

+531.10%

TGTXTG THERAPEUTICS INC

+2.0

+149.08%

KODKODIAK SCIENCES INC

+2.0

+3,654.51%

MDGLMADRIGAL PHARMACEUTICALS INC

+2.0

+126.36%

IBRXIMMUNITYBIO INC

+1.9

+206.41%

KRYSKRYSTAL BIOTECH INC

+1.7

+87.23%

TVTXTRAVERE THERAPEUTICS INC

+1.7

+242.25%

SYRESPYRE THERAPEUTICS INC

+1.6

+193.96%

CELCCELCUITY INC

+1.6

+351.73%

VCYTVERACYTE INC

+1.6

+37.73%

CRSPCRISPR THERAPEUTICS AG

+1.5

+17.68%

127 othersclick to expand the full index

+35.7

VKTXVIKING THERAPEUTICS INC

−0.5

−56.11%

BMRNBIOMARIN PHARMACEUTICAL INC

−0.6

−21.17%

SPRYARS PHARMACEUTICALS INC

−0.6

−70.19%

PCVXVAXCYTE INC

−0.6

−35.86%

CAPRCAPRICOR THERAPEUTICS INC

−0.6

−63.83%

ADMAADMA BIOLOGICS INC

−0.6

−48.94%

MYGNMYRIAD GENETICS INC

−0.7

−83.72%

ALNYALNYLAM PHARMACEUTICALS INC

−0.8

−13.18%

QUREUNIQURE NV

−1.1

+299.82%

GERNGERON CORP

−1.1

−71.64%

JBIOJADE BIOSCIENCES INC

−1.2

−75.20%

DYNDYNE THERAPEUTICS INC

−1.3

−48.93%

BHVNBIOHAVEN LTD

−1.5

−74.62%

RAREULTRAGENYX PHARMACEUTICAL IN

−1.8

−71.22%

SRPTSAREPTA THERAPEUTICS INC

−4.8

−85.17%

Cap weighting, illustrated

MADRIGAL PHARMACEUTICALS INC and OVID THERAPEUTICS INC moved almost identically (+126.36% vs +113.91%), yet MDGL moved the XBI 136.8× as much. In a cap-weighted index, the bigger company's weight turns the same percentage move into far more points.

Attribution map

slicing the +56.24 pt move · cell size = points contributed · color = direction, intensity = return

SRPT−4.8 pts(−85.2%)

MRNA+3.9 pts(+273.8%)

TWST+3.1 pts(+268.7%)

GRAL+2.7 pts(+978.9%)

NTRA

ERAS

TGTX+2.0 pts(+149.1%)

KOD+2.0 pts(+3,654.5%)

MDGL+2.0 pts(+126.4%)

IBRX+1.9 pts(+206.4%)

RARE−1.8 pts

KRYS+1.7 pts

TVTX+1.7 pts

SYRE+1.6 pts

CELC+1.6 pts

VCYT+1.6 pts

CRSP+1.5 pts

BHVN

PTCT

PTGX+1.4 pts

CDNA+1.4 pts

BEAM

IOVA+1.4 pts

ORKA+1.3 pts

KYMR+1.3 pts

RVMD+1.3 pts

DYN

ROIV

SLS+1.3 pts

EXEL+1.3 pts

BBIO

JBIO−1.2 pts

DNTH+1.2 pts

HALO

ARWR

PVLA

GILD

INCY

GERN

ABBV+1.1 pts

RYTM+1.1 pts

COGT

NVAX

SRRK

PURR

RLAY

ALNY

CGON

MYGN

37 more

ABSI

ADMA

CAPR

TNGX

BMRN

CYTK

ZBIO

ARDX

PGEN

REGN

NKTR

PRAX

MNKD

BIIB

Concentration curve

cumulative share of the +56.24 pt move · sorted by contribution

When they drove it

cumulative points through the period

Breadth

member returns, this period

−100%+100%+300%+500%+700%+900%+1,100%+1,300%+1,500%+1,700%+1,900%+2,100%+2,300%+2,500%+2,700%+2,900%+3,100%+3,300%+3,500%

From −85.17% (SRPT) to +3,654.51% (KOD). Equal-weight, the XBI would be +140.06% vs the actual +57.68%; the gap is what cap weighting did.

By sector

point contribution · sums to +56.24 pts

-157

+49.7

The year, session by session

every trading day of 2026 · hover for the move

JANFEBMARAPRMAYJUNJULAUGSEPOCT

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SPDR S&P Biotech ETF

What drove it

Attribution map

Concentration curve

When they drove it

Breadth

By sector

The year, session by session

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