XBI · WMTMT

Oct 1, 2021Jan 4, 2023Apr 9, 2024Jul 9, 2025Oct 9, 2026

Breadth

70 / 157

stocks rose with the index

Concentration

31%

of the gain from TWST, NTRA, GRAL

Biggest driver

TWST +3.05

TWIST BIOSCIENCE CORP, +51.45%

Biggest drag

AVTX −69.02

AVALO THERAPEUTICS INC, −99.79%

What drove it

157 members · drivers first · 5Y · residual 7525.6bp exceeds 60bp gate

The XBI rose 21.86% (+27.58 pts) over five years, but 87 of 157 members went the other way. TWST and NTRA carried the tape higher, accounting for 31% of the gain.

Read the latest market-close note: Goldman and Microsoft Push the Dow to a Large Gain While Telecoms Sink Communication Services

+84.3 pts from 94 gainers−110.7 pts from 63 losers

net +27.6 pts · losers outweigh gainers 1.3 to 1

Stock

Points

Return

XBIsum of all 157 stocks

+27.6

+21.86%

TWSTTWIST BIOSCIENCE CORP

+3.0

+51.45%

NTRANATERA INC

+2.9

+256.54%

GRALGRAIL INC

+2.6

+726.94%

TGTXTG THERAPEUTICS INC

+2.5

+64.25%

IBRXIMMUNITYBIO INC

+2.5

+5.00%

KRYSKRYSTAL BIOTECH INC

+2.3

+515.35%

PTCTPTC THERAPEUTICS INC

+2.1

+65.81%

MDGLMADRIGAL PHARMACEUTICALS INC

+1.9

+486.39%

PTGXPROTAGONIST THERAPEUTICS INC

+1.8

+700.72%

RVMDREVOLUTION MEDICINES INC

+1.8

+551.65%

VKTXVIKING THERAPEUTICS INC

+1.8

+364.33%

DNTHDIANTHUS THERAPEUTICS INC

+1.7

+648.82%

CELCCELCUITY INC

+1.7

+283.41%

TVTXTRAVERE THERAPEUTICS INC

+1.7

+108.33%

CRSPCRISPR THERAPEUTICS AG

+1.6

−52.03%

127 othersclick to expand the full index

+43.7

SANASANA BIOTECHNOLOGY INC

−0.7

−86.90%

MYGNMYRIAD GENETICS INC

−0.7

−86.48%

VIRVIR BIOTECHNOLOGY INC

−0.7

−65.94%

SYRESPYRE THERAPEUTICS INC

−0.8

−58.20%

EBSEMERGENT BIOSOLUTIONS INC

−1.0

−87.18%

ALLOALLOGENE THERAPEUTICS INC

−1.1

−94.05%

QUREUNIQURE NV

−1.1

−29.47%

VORVOR BIOPHARMA INC

−1.2

−93.56%

BMRNBIOMARIN PHARMACEUTICAL INC

−1.5

−28.99%

NTLAINTELLIA THERAPEUTICS INC

−2.8

−90.25%

RAREULTRAGENYX PHARMACEUTICAL IN

−3.2

−82.37%

NVAXNOVAVAX INC

−5.9

−92.98%

JBIOJADE BIOSCIENCES INC

−5.9

−97.45%

SRPTSAREPTA THERAPEUTICS INC

−6.6

−81.42%

AVTXAVALO THERAPEUTICS INC

−69.0

−99.79%

Cap weighting, illustrated

AVALO THERAPEUTICS INC and OCUGEN INC moved almost identically (−99.79% vs −86.31%), yet AVTX moved the XBI 2,241.3× as much. In a cap-weighted index, the bigger company's weight turns the same percentage move into far more points.

Attribution map

slicing the +27.58 pt move · cell size = points contributed · color = direction, intensity = return

AVTX−69.0 pts(−99.8%)

SRPT−6.6 pts(−81.4%)

JBIO−5.9 pts(−97.5%)

NVAX−5.9 pts(−93.0%)

RARE

TWST+3.0 pts

NTRA+2.9 pts

NTLA−2.8 pts

GRAL+2.6 pts

TGTX

IBRX

KRYS

PTCT+2.1 pts

MDGL+1.9 pts

RVMD

VKTX

DNTH

TVTX+1.7 pts

CRSP

PCVX

HALO

KYMR+1.4 pts

ORKA+1.4 pts

EXEL

BBIO

RYTM

ADMA

CYTK

VOR

KOD

QURE

IMVT

INSM

INCY

MRNA

EBS

DMRA

CGON

SYRE

VIR

TNGX

IONS

MIRM

Concentration curve

cumulative share of the +27.58 pt move · sorted by contribution

When they drove it

cumulative points through the period

Breadth

member returns, this period

−100%+100%+300%+500%+700%+900%

From −99.79% (AVTX) to +981.61% (PVLA). Equal-weight, the XBI would be +247.31% vs the actual +21.86%; the gap is what cap weighting did.

By sector

point contribution · sums to +27.58 pts

-157

−26.4

The year, session by session

every trading day of 2026 · hover for the move

JANFEBMARAPRMAYJUNJULAUGSEPOCT

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SPDR S&P Biotech ETF

What drove it

Attribution map

Concentration curve

When they drove it

Breadth

By sector

The year, session by session

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