XBI · WMTMT

Aug 18, 2021Nov 17, 2022Feb 23, 2024May 22, 2025Aug 26, 2026

Breadth

81 / 147

stocks rose with the index

Concentration

16%

of the gain from VKTX, APGE, RYTM

Biggest driver

VKTX +2.83

VIKING THERAPEUTICS INC, +502.10%

Biggest drag

AVTX −78.65

AVALO THERAPEUTICS INC, −99.74%

What drove it

147 members · drivers first · 5Y · residual 10049.8bp exceeds 60bp gate

The XBI rose 38.47% (+46.78 pts) over five years, but 66 of 147 members went the other way. VKTX and APGE carried the tape higher, accounting for 16% of the gain.

Read the latest market-close note: A Flat Headline on the S&P 500 Masks a Split Between Goldman Sachs and Apple

+96.3 pts from 106 gainers−120.3 pts from 41 losers

net +46.8 pts · losers outweigh gainers 1.2 to 1

Stock

Points

Return

XBIsum of all 147 stocks

+46.8

+38.47%

VKTXVIKING THERAPEUTICS INC

+2.8

+502.10%

APGEAPOGEE THERAPEUTICS INC

+2.4

+535.66%

RYTMRHYTHM PHARMACEUTICALS INC

+2.3

+791.39%

TWSTTWIST BIOSCIENCE CORP

+2.2

+54.67%

IMVTIMMUNOVANT INC

+2.2

+465.59%

DNTHDIANTHUS THERAPEUTICS INC

+2.0

+906.91%

IBRXIMMUNITYBIO INC

+1.9

−11.76%

SRRKSCHOLAR ROCK HOLDING CORP

+1.9

+42.24%

ORKAORUKA THERAPEUTICS INC

+1.9

+375.03%

KRYSKRYSTAL BIOTECH INC

+1.9

+559.26%

NTRANATERA INC

+1.8

+233.57%

ADMAADMA BIOLOGICS INC

+1.8

+652.34%

HALOHALOZYME THERAPEUTICS INC

+1.8

+170.90%

CGONCG ONCOLOGY INC

+1.8

+110.98%

RVMDREVOLUTION MEDICINES INC

+1.8

+709.62%

117 othersclick to expand the full index

+59.6

MPLTMAPLIGHT THERAPEUTICS INC

−0.7

−29.88%

SANASANA BIOTECHNOLOGY INC

−0.7

−79.98%

MYGNMYRIAD GENETICS INC

−0.8

−90.51%

ALTALTIMMUNE INC

−0.9

−73.53%

VIRVIR BIOTECHNOLOGY INC

−1.2

−76.04%

CAPRCAPRICOR THERAPEUTICS INC

−1.4

+138.17%

JBIOJADE BIOSCIENCES INC

−1.7

−94.07%

RXRXRECURSION PHARMACEUTICALS A

−2.2

−81.66%

VORVOR BIOPHARMA INC

−2.2

−91.56%

MRNAMODERNA INC

−2.4

−62.47%

NTLAINTELLIA THERAPEUTICS INC

−3.2

−91.35%

RAREULTRAGENYX PHARMACEUTICAL IN

−3.7

−67.74%

SRPTSAREPTA THERAPEUTICS INC

−4.2

−74.05%

NVAXNOVAVAX INC

−10.0

−95.94%

AVTXAVALO THERAPEUTICS INC

−78.6

−99.74%

Cap weighting, illustrated

SAREPTA THERAPEUTICS INC and MIMEDX GROUP INC moved almost identically (−74.05% vs −64.01%), yet SRPT moved the XBI 286.1× as much. In a cap-weighted index, the bigger company's weight turns the same percentage move into far more points.

Attribution map

slicing the +46.78 pt move · cell size = points contributed · color = direction, intensity = return

AVTX−78.6 pts(−99.7%)

NVAX−10.0 pts(−95.9%)

SRPT−4.2 pts

RARE

NTLA−3.2 pts

VKTX+2.8 pts

MRNA

APGE

RYTM

VOR

RXRX

TWST

IMVT

DNTH

IBRX

SRRK

ORKA

KRYS

MDGL

JBIO

TVTX

VRDN

COGT

CAPR

PTCT

CELC

VIR

AMGN

ERAS

IRON

REGN

VRTX

PRAX

SLS

BHVN

INCY

PCVX

INSM

BEAM

VERA

IONS

ARQT

ACAD

UTHR

Concentration curve

cumulative share of the +46.78 pt move · sorted by contribution

When they drove it

cumulative points through the period

Breadth

member returns, this period

−100%+100%+300%+500%+700%+900%+1,100%

From −99.74% (AVTX) to +1,102.88% (PVLA). Equal-weight, the XBI would be +326.29% vs the actual +38.47%; the gap is what cap weighting did.

By sector

point contribution · sums to +46.78 pts

-147

−24.1

The year, session by session

every trading day of 2026 · hover for the move

JANFEBMARAPRMAYJUNJULAUG

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SPDR S&P Biotech ETF

What drove it

Attribution map

Concentration curve

When they drove it

Breadth

By sector

The year, session by session

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