XBI · WMTMT

Aug 18, 2023May 21, 2024Feb 24, 2025Nov 19, 2025Aug 25, 2026

Breadth

113 / 147

stocks rose with the index

Concentration

of the gain from MRNA, TWST, NTRA

Biggest driver

MRNA +3.44

MODERNA INC, +56.30%

Biggest drag

JBIO −8.66

JADE BIOSCIENCES INC, −94.64%

What drove it

147 members · drivers first · 3Y · residual 3461.7bp exceeds 60bp gate

The XBI rose 118.13% (+91.59 pts) over three years in a broad advance: 113 of 147 stocks rose, with MRNA out front at +3.44 points.

Read the latest market-close note: Nvidia and Goldman Sachs Lead a Narrow Advance as Energy and Staples Slide

+96.9 pts from 114 gainers−26.5 pts from 33 losers

net +91.6 pts · gainers outweigh losers 3.7 to 1

Stock

Points

Return

XBIsum of all 147 stocks

+91.6

+118.13%

MRNAMODERNA INC

+3.4

+56.30%

TWSTTWIST BIOSCIENCE CORP

+2.7

+678.11%

NTRANATERA INC

+2.1

+540.13%

APGEAPOGEE THERAPEUTICS INC

+2.1

+456.31%

PTGXPROTAGONIST THERAPEUTICS INC

+2.0

+687.19%

ERASERASCA INC

+2.0

+607.57%

KYMRKYMERA THERAPEUTICS INC

+1.9

+542.19%

DNTHDIANTHUS THERAPEUTICS INC

+1.9

+919.18%

SRRKSCHOLAR ROCK HOLDING CORP

+1.9

+805.91%

MDGLMADRIGAL PHARMACEUTICALS INC

+1.9

+184.94%

RYTMRHYTHM PHARMACEUTICALS INC

+1.9

+351.23%

ORKAORUKA THERAPEUTICS INC

+1.9

+575.94%

TVTXTRAVERE THERAPEUTICS INC

+1.8

+393.81%

SYRESPYRE THERAPEUTICS INC

+1.8

+776.41%

VKTXVIKING THERAPEUTICS INC

+1.8

+144.42%

117 othersclick to expand the full index

+63.2

MYGNMYRIAD GENETICS INC

−0.3

−81.35%

PRMEPRIME MEDICINE INC

−0.3

−68.90%

MPLTMAPLIGHT THERAPEUTICS INC

−0.3

−31.62%

SANASANA BIOTECHNOLOGY INC

−0.4

−24.63%

BMRNBIOMARIN PHARMACEUTICAL INC

−0.5

−25.75%

GERNGERON CORP

−0.6

−40.61%

ALTALTIMMUNE INC

−0.6

+20.75%

CAPRCAPRICOR THERAPEUTICS INC

−0.7

+19.97%

PRTAPROTHENA CORP PLC

−0.8

−83.40%

VORVOR BIOPHARMA INC

−0.9

−59.03%

NTLAINTELLIA THERAPEUTICS INC

−1.4

−64.06%

RAREULTRAGENYX PHARMACEUTICAL IN

−1.5

−24.59%

RXRXRECURSION PHARMACEUTICALS A

−1.7

−58.51%

SRPTSAREPTA THERAPEUTICS INC

−5.4

−83.09%

JBIOJADE BIOSCIENCES INC

−8.7

−94.64%

Cap weighting, illustrated

SAREPTA THERAPEUTICS INC and CABALETTA BIO INC moved almost identically (−83.09% vs −74.61%), yet SRPT moved the XBI 64.2× as much. In a cap-weighted index, the bigger company's weight turns the same percentage move into far more points.

Attribution map

slicing the +91.59 pt move · cell size = points contributed · color = direction, intensity = return

JBIO−8.7 pts(−94.6%)

SRPT−5.4 pts

MRNA+3.4 pts(+56.3%)

TWST+2.7 pts(+678.1%)

NTRA+2.1 pts

APGE+2.1 pts

PTGX+2.0 pts

ERAS+2.0 pts

KYMR+1.9 pts(+542.2%)

DNTH+1.9 pts(+919.2%)

SRRK+1.9 pts(+805.9%)

MDGL+1.9 pts

RYTM+1.9 pts

ORKA

TVTX+1.8 pts

SYRE+1.8 pts

VKTX+1.8 pts

TGTX+1.7 pts

RXRX

GRAL

SLS+1.6 pts

ADMA+1.6 pts

RVMD+1.5 pts

CELC

NVAX

ROIV

RARE

HALO+1.4 pts

KRYS+1.4 pts

NTLA−1.4 pts

IOVA+1.3 pts

ARQT+1.3 pts

PVLA

INSM

CRSP+1.2 pts

COGT+1.1 pts

DYN

EXEL

BBIO

PURR+0.9 pts

CYTK+0.9 pts

CDNA

PTCT

VRDN

PRTA

IMNM

VCYT

IDYA

AMGN

ARWR

CAPR

MLYS

VRTX

TNGX

27 more

KOD

ALT

DNLI

BMRN

REGN

PGEN

ALKS

INBX

CLDX

XNCR

Concentration curve

cumulative share of the +91.59 pt move · sorted by contribution

When they drove it

cumulative points through the period

Breadth

member returns, this period

−100%+100%+300%+500%+700%+900%+1,100%+1,300%+1,500%

From −94.64% (JBIO) to +1,603.80% (PRAX). Equal-weight, the XBI would be +375.01% vs the actual +118.13%; the gap is what cap weighting did.

By sector

point contribution · sums to +91.59 pts

-147

+70.4

The year, session by session

every trading day of 2026 · hover for the move

JANFEBMARAPRMAYJUNJULAUG

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SPDR S&P Biotech ETF

What drove it

Attribution map

Concentration curve

When they drove it

Breadth

By sector

The year, session by session

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