XBI · WMTMT

Apr 10May 27Jul 13Aug 26Oct 9

Breadth

77 / 157

stocks rose with the index

Concentration

36%

of the gain from MRNA, TWST, IOVA

Biggest driver

MRNA +3.62

MODERNA INC, +341.52%

Biggest drag

IONS −1.51

IONIS PHARMACEUTICALS INC, −39.76%

What drove it

157 members · drivers first · 6M · residual 683.2bp exceeds 60bp gate

The XBI rose 18.78% (+24.31 pts) over the past six months, but 80 of 157 members went the other way. MRNA and TWST carried the tape higher, accounting for 36% of the gain.

Read the latest market-close note: Goldman and Microsoft Push the Dow to a Large Gain While Telecoms Sink Communication Services

+37.7 pts from 80 gainers−14.2 pts from 77 losers

net +24.3 pts · gainers outweigh losers 2.7 to 1

Stock

Points

Return

XBIsum of all 157 stocks

+24.3

+18.78%

MRNAMODERNA INC

+3.6

+341.52%

TWSTTWIST BIOSCIENCE CORP

+3.0

+233.50%

IOVAIOVANCE BIOTHERAPEUTICS INC

+2.2

+295.14%

GRALGRAIL INC

+1.8

+208.09%

NTRANATERA INC

+1.8

+107.59%

RVMDREVOLUTION MEDICINES INC

+1.3

+96.79%

CDNACAREDX INC

+1.3

+296.70%

TGTXTG THERAPEUTICS INC

+1.2

+64.16%

VCYTVERACYTE INC

+1.1

+45.48%

KODKODIAK SCIENCES INC

+1.1

+131.66%

TVTXTRAVERE THERAPEUTICS INC

+1.0

+79.99%

HALOHALOZYME THERAPEUTICS INC

+1.0

+62.81%

SYRESPYRE THERAPEUTICS INC

+0.9

+67.07%

EXELEXELIXIS INC

+0.8

+35.22%

SLSSELLAS LIFE SCIENCES GROUP I

+0.8

+144.75%

127 othersclick to expand the full index

+9.4

DNTHDIANTHUS THERAPEUTICS INC

−0.3

−8.24%

CMPXCOMPASS THERAPEUTICS INC

−0.3

−80.79%

TYRATYRA BIOSCIENCES INC

−0.3

−43.45%

PRAXPRAXIS PRECISION MEDICINES I

−0.3

−17.80%

MDGLMADRIGAL PHARMACEUTICALS INC

−0.3

−9.21%

ARDXARDELYX INC

−0.3

−46.93%

VERAVERA THERAPEUTICS INC

−0.5

−33.66%

NKTRNEKTAR THERAPEUTICS

−0.5

−45.85%

VKTXVIKING THERAPEUTICS INC

−0.5

−16.78%

CAPRCAPRICOR THERAPEUTICS INC

−0.6

−74.90%

RAREULTRAGENYX PHARMACEUTICAL IN

−0.7

−33.56%

ALNYALNYLAM PHARMACEUTICALS INC

−0.8

−27.76%

CELCCELCUITY INC

−0.8

−42.00%

INSMINSMED INC

−1.0

−35.02%

IONSIONIS PHARMACEUTICALS INC

−1.5

−39.76%

Cap weighting, illustrated

TG THERAPEUTICS INC and SAGIMET BIOSCIENCES INC A moved almost identically (+64.16% vs +68.49%), yet TGTX moved the XBI 55.3× as much. In a cap-weighted index, the bigger company's weight turns the same percentage move into far more points.

Attribution map

slicing the +24.31 pt move · cell size = points contributed · color = direction, intensity = return

MRNA+3.6 pts(+341.5%)

TWST+3.0 pts(+233.5%)

IOVA+2.2 pts

GRAL+1.8 pts(+208.1%)

NTRA+1.8 pts(+107.6%)

IONS−1.5 pts(−39.8%)

RVMD+1.3 pts(+96.8%)

CDNA+1.3 pts(+296.7%)

TGTX+1.2 pts

VCYT+1.1 pts

KOD+1.1 pts(+131.7%)

TVTX+1.0 pts(+80.0%)

HALO+1.0 pts(+62.8%)

INSM−1.0 pts

SYRE+0.9 pts

CELC−0.8 pts

ALNY−0.8 pts

EXEL+0.8 pts

SLS+0.8 pts

KRYS

PTGX

RARE−0.7 pts

IBRX+0.7 pts

PURR

ABBV+0.6 pts

CAPR−0.6 pts

BIIB

ABSI

KYMR

VKTX−0.5 pts

NKTR−0.5 pts

AMGN

PCVX

ERAS

VRTX

PGEN

CRSP

37 more

RLAY

NVAX

ROIV

MDGL

CMPX

DNTH

NRIX

QURE

ACAD

SRRK

INBX

TRAX

IMVT

TNGX

SNDX

CGON

SRPT

STOK

Concentration curve

cumulative share of the +24.31 pt move · sorted by contribution

When they drove it

cumulative points through the period

Breadth

member returns, this period

−100%0%+100%+200%+300%

From −80.79% (CMPX) to +341.52% (MRNA). Equal-weight, the XBI would be +17.65% vs the actual +18.78%; the gap is what cap weighting did.

By sector

point contribution · sums to +24.31 pts

-157

+23.5

The year, session by session

every trading day of 2026 · hover for the move

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SPDR S&P Biotech ETF

What drove it

Attribution map

Concentration curve

When they drove it

Breadth

By sector

The year, session by session

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