XBI · WMTMT

Feb 25Apr 13May 27Jul 14Aug 26

Breadth

99 / 147

stocks rose with the index

Concentration

18%

of the gain from MRNA, TWST, APGE

Biggest driver

MRNA +3.78

MODERNA INC, +191.34%

Biggest drag

CAPR −1.78

CAPRICOR THERAPEUTICS INC, −66.98%

What drove it

147 members · drivers first · 6M · residual 442.0bp exceeds 60bp gate

The XBI rose 31.27% (+40.11 pts) over the past six months on a mixed tape; MRNA, TWST, APGE did most of the lifting, with 18% of the gain between them.

Read the latest market-close note: A Flat Headline on the S&P 500 Masks a Split Between Goldman Sachs and Apple

+47.9 pts from 110 gainers−7.7 pts from 37 losers

net +40.1 pts · gainers outweigh losers 6.3 to 1

Stock

Points

Return

XBIsum of all 147 stocks

+40.1

+31.27%

MRNAMODERNA INC

+3.8

+191.34%

TWSTTWIST BIOSCIENCE CORP

+2.1

+205.41%

APGEAPOGEE THERAPEUTICS INC

+1.2

+90.37%

ORKAORUKA THERAPEUTICS INC

+1.2

+181.86%

TVTXTRAVERE THERAPEUTICS INC

+1.2

+128.77%

RVMDREVOLUTION MEDICINES INC

+1.2

+108.68%

RLAYRELAY THERAPEUTICS INC

+1.1

+111.06%

SYRESPYRE THERAPEUTICS INC

+1.1

+113.32%

DNTHDIANTHUS THERAPEUTICS INC

+1.0

+113.53%

PTGXPROTAGONIST THERAPEUTICS INC

+1.0

+73.94%

IOVAIOVANCE BIOTHERAPEUTICS INC

+1.0

+110.97%

SLSSELLAS LIFE SCIENCES GROUP I

+0.9

+201.76%

PURRHYPERLIQUID STRATEGIES

+0.9

+179.23%

ERASERASCA INC

+0.9

+42.27%

CGONCG ONCOLOGY INC

+0.9

+37.60%

117 othersclick to expand the full index

+26.9

ORICORIC PHARMACEUTICALS INC

−0.2

+3.81%

CRVSCORVUS PHARMACEUTICALS INC

−0.2

−19.07%

CMPXCOMPASS THERAPEUTICS INC

−0.2

−58.74%

CTMXCYTOMX THERAPEUTICS INC

−0.2

−42.56%

ARDXARDELYX INC

−0.3

−41.62%

SIONSIONNA THERAPEUTICS INC

−0.3

−83.78%

VERAVERA THERAPEUTICS INC

−0.3

−11.66%

ADMAADMA BIOLOGICS INC

−0.3

−38.58%

ALNYALNYLAM PHARMACEUTICALS INC

−0.3

−26.99%

IONSIONIS PHARMACEUTICALS INC

−0.3

−21.71%

CELCCELCUITY INC

−0.4

−11.45%

OLMAOLEMA PHARMACEUTICALS INC

−0.4

−54.98%

INSMINSMED INC

−0.5

−16.30%

MPLTMAPLIGHT THERAPEUTICS INC

−0.7

−27.06%

CAPRCAPRICOR THERAPEUTICS INC

−1.8

−66.98%

Cap weighting, illustrated

CELCUITY INC and MINERALYS THERAPEUTICS INC moved almost identically (−11.45% vs −11.43%), yet CELC moved the XBI 36.6× as much. In a cap-weighted index, the bigger company's weight turns the same percentage move into far more points.

Attribution map

slicing the +40.11 pt move · cell size = points contributed · color = direction, intensity = return

MRNA+3.8 pts(+191.3%)

TWST+2.1 pts

CAPR−1.8 pts(−67.0%)

APGE+1.2 pts(+90.4%)

ORKA+1.2 pts(+181.9%)

TVTX+1.2 pts(+128.8%)

RVMD+1.2 pts(+108.7%)

RLAY+1.1 pts(+111.1%)

SYRE+1.1 pts(+113.3%)

DNTH+1.0 pts(+113.5%)

PTGX+1.0 pts

IOVA+1.0 pts

SLS+0.9 pts

PURR+0.9 pts

ERAS+0.9 pts

CGON+0.9 pts

TGTX

NTRA

DYN+0.8 pts

HALO+0.8 pts

IMVT

KRYS+0.7 pts

GRAL+0.7 pts

SRRK+0.7 pts

ARWR+0.7 pts

MPLT

TRAX

ALKS+0.7 pts

KYMR+0.6 pts

CDNA

RYTM

TNGX

XNCR+0.5 pts

ABSI+0.5 pts

IMNM

INSM

CRSP

RCUS

CYTK

EXEL

BCRX

OLMA

ACAD

CELC

PGEN

IONS

ALNY

ZBIO

AMGN

IRON

MDGL

ADMA

VERA

SION

BBIO

VCYT

CTMX

VKTX

NTLA

BIIB

KURA

BMRN

Concentration curve

cumulative share of the +40.11 pt move · sorted by contribution

When they drove it

cumulative points through the period

Breadth

member returns, this period

−100%0%+100%+200%

From −83.78% (SION) to +236.50% (ABSI). Equal-weight, the XBI would be +35.00% vs the actual +31.27%; the gap is what cap weighting did.

By sector

point contribution · sums to +40.11 pts

-147

+40.2

The year, session by session

every trading day of 2026 · hover for the move

JANFEBMARAPRMAYJUNJULAUG

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SPDR S&P Biotech ETF

What drove it

Attribution map

Concentration curve

When they drove it

Breadth

By sector

The year, session by session

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