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WHAT MOVED THE MARKET TODAY

SPDR S&P Biotech ETF

147 stocks · cap-weighted, ETF-derived weights · Aug 25, 2026 close
169.12
+10.87 (+6.87%)
XBI 169.12 · +10.9 pts (+6.87%) QTD
173.28166.28159.28152.29145.29EW +8.41%H 169.55 · Aug 19L 147.01 · Jul 31
Jun 30Jul 15Jul 29Aug 11Aug 25
Breadth
87 / 147
stocks rose with the index
Concentration
45%
of the gain from MRNA, TWST, IOVA
Biggest driver
MRNA +2.92
MODERNA INC, +126.80%
Biggest drag
CAPR −0.95
CAPRICOR THERAPEUTICS INC, −65.57%

What drove it

147 members · drivers first · QTD · residual 11.6bp within 60bp gate

The XBI rose 6.87% (+10.87 pts) so far this quarter on a mixed tape; MRNA, TWST, IOVA did most of the lifting, with 45% of the gain between them.

Read the latest market-close note: Nvidia and Goldman Sachs Lead a Narrow Advance as Energy and Staples Slide

+19.4 pts from 87 gainers8.6 pts from 60 losers
net +10.9 pts · gainers outweigh losers 2.3 to 1
Stock
Points
Return
XBIsum of all 147 stocks
+10.9
100%
+6.87%
MRNAMODERNA INC
+2.9
27%
+126.80%
TWSTTWIST BIOSCIENCE CORP
+1.1
10%
+47.18%
IOVAIOVANCE BIOTHERAPEUTICS INC
+0.9
8%
+102.88%
HALOHALOZYME THERAPEUTICS INC
+0.7
6%
+39.67%
REGNREGENERON PHARMACEUTICALS
+0.6
5%
+33.68%
PURRHYPERLIQUID STRATEGIES
+0.5
5%
+50.83%
TRAXFIRST TRACKS BIOTHERAPEUTICS
+0.5
5%
+124.20%
NTRANATERA INC
+0.5
5%
+24.04%
IMNMIMMUNOME INC
+0.4
4%
+38.67%
XNCRXENCOR INC
+0.4
4%
+81.99%
CDNACAREDX INC
+0.4
3%
+78.25%
PTGXPROTAGONIST THERAPEUTICS INC
+0.3
3%
+22.85%
ACADACADIA PHARMACEUTICALS INC
+0.3
3%
+20.83%
VRDNVIRIDIAN THERAPEUTICS INC
+0.3
3%
+31.63%
SYRESPYRE THERAPEUTICS INC
+0.3
3%
+20.93%
117 othersclick to expand the full index
+6.2
57%
·
ALNYALNYLAM PHARMACEUTICALS INC
−0.2
−2%
−20.25%
CELCCELCUITY INC
−0.2
−2%
−11.80%
NTLAINTELLIA THERAPEUTICS INC
−0.2
−2%
−20.15%
TNGXTANGO THERAPEUTICS INC
−0.3
−2%
−20.76%
IBRXIMMUNITYBIO INC
−0.3
−3%
−6.45%
VCYTVERACYTE INC
−0.3
−3%
−25.01%
IONSIONIS PHARMACEUTICALS INC
−0.3
−3%
−19.83%
SIONSIONNA THERAPEUTICS INC
−0.3
−3%
−85.79%
RAREULTRAGENYX PHARMACEUTICAL IN
−0.3
−3%
−20.75%
GLUEMONTE ROSA THERAPEUTICS INC
−0.4
−3%
−39.83%
MIRMMIRUM PHARMACEUTICALS INC
−0.4
−4%
−16.22%
VERAVERA THERAPEUTICS INC
−0.4
−4%
−17.78%
SLSSELLAS LIFE SCIENCES GROUP I
−0.4
−4%
−4.54%
MPLTMAPLIGHT THERAPEUTICS INC
−0.4
−4%
−65.01%
CAPRCAPRICOR THERAPEUTICS INC
−0.9
−9%
−65.57%
Cap weighting, illustrated

SELLAS LIFE SCIENCES GROUP I and ARCUTIS BIOTHERAPEUTICS INC moved almost identically (−4.54% vs −5.19%), yet SLS moved the XBI 33.8× as much. In a cap-weighted index, the bigger company's weight turns the same percentage move into far more points.

Attribution map

slicing the +10.87 pt move · cell size = points contributed · color = direction, intensity = return
MRNA+2.9 pts(+126.8%)
TWST+1.1 pts
CAPR−0.9 pts(−65.6%)
IOVA+0.9 pts
HALO+0.7 pts
REGN+0.6 pts(+33.7%)
PURR+0.5 pts(+50.8%)
TRAX+0.5 pts
NTRA+0.5 pts
MPLT−0.4 pts
SLS−0.4 pts
VERA−0.4 pts
IMNM+0.4 pts
MIRM−0.4 pts
XNCR
CDNA
GLUE−0.4 pts
PTGX+0.3 pts
ACAD+0.3 pts
VRDN
SYRE
DYN
SION
AMGN+0.3 pts
CRSP+0.3 pts
IDYA+0.3 pts
TVTX+0.3 pts
CGON
IBRX
ARWR
GILD
GRAL
BMRN
NTLA−0.2 pts
ADMA+0.2 pts
RLAY+0.2 pts
ALNY−0.2 pts
CYTK
KYMR
DNTH
RVMD
CGEM
ZBIO
SRRK
PGEN
BBIO
INBX
VSTM
ABSI
IMMX
ARDX
QURE
ANAB
CADL
RIGL
MYGN
UTHR
SNDX
PTCT
REPL
MLYS
JANX
ALKS
MNKD

Concentration curve

cumulative share of the +10.87 pt move · sorted by contribution
0%50%100%3774110147stocks:3 stocks = 45%100% covered at 18

When they drove it

cumulative points through the period
0MRNA +2.92TWST +1.06IOVA +0.86CAPR −0.95MPLT −0.44SLS −0.43Jun 30Aug 25

Breadth

member returns, this period
−100%−50%0%+50%+100%
From −85.79% (SION) to +126.80% (MRNA). Equal-weight, the XBI would be +8.41% vs the actual +6.87%; the gap is what cap weighting did.

By sector

point contribution · sums to +10.87 pts
-147
+10.8

The year, session by session

every trading day of 2026 · hover for the move
JANFEBMARAPRMAYJUNJULAUG

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